:: Volume 2, Issue 2 (3-2006) ::
JSRI 2006, 2(2): 187-196 Back to browse issues page
A New S-­test for Haplotype Analysis: Concordance and Discordance
Mahnaz Khattak, Shuhrat Shah, Salahuddin Salahuddin *1
1- , salahuddin_90@hotmail.com
Abstract:   (2304 Views)

A new test of inheritance, S, is proposed, which uses information from affected as well as unaffected siblings in the fam­ ily. The siblings are analyzed in terms of similarities of haplotypes. The distribution of the proposed S­test is derived under the null hypothesis of random inheritance. Mean and variance are obtained for the distribution. The test is then applied to data sets published in the literature. The results suggest some sort of linkage between haplotypes and disease genes.

Keywords: genetics, haplotypes, S­test.
Full-Text [PDF 227 kb]   (536 Downloads)    
Type of Study: Research | Subject: General
Received: 2016/02/13 | Accepted: 2016/02/13 | Published: 2016/02/13


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Volume 2, Issue 2 (3-2006) Back to browse issues page