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:: Volume 15, Issue 2 (3-2019) ::
JSRI 2019, 15(2): 213-236 Back to browse issues page
Bayesian Sample Size Determination for Joint Modeling of Longitudinal Measurements and Survival Data
Taban Baghfalaki *
Tarbiat Modares University , t.baghfalaki@modares.ac.ir
Abstract:   (32 Views)

A longitudinal study refers to collection of a response variable and possibly some explanatory variables at multiple follow-up times. In many clinical studies with longitudinal measurements, the response variable, for each patient is collected as long as an event of interest, which considered as clinical end point, occurs. Joint modeling of continuous longitudinal measurements and survival time is an approach for accounting association between two outcomes which frequently discussed in the literature, but design aspects of these models have been rarely considered.

This paper uses a simulation-based method to determine the sample size from a Bayesian perspective. For this purpose, several Bayesian criteria for sample size determination are used, of which the most important one is the Bayesian power criterion (BPC), where the determined sample sizes are given based on BPC. We determine the sample size based on treatment effect on both outcomes (longitudinal measurements and survival time). The sample size determination is performed

based on multiple hypotheses. Using several examples, the proposed Bayesian methods are illustrated and discussed. All the implementations are performed using R2OpenBUGS package and R 3.5.1 software. 

Keywords: Bayesian analysis, bayesian power criterion, longitudinal data, sample size determination, survival data, shared parameter model.
Full-Text [PDF 270 kb]   (15 Downloads)    
Type of Study: Research | Subject: General
Received: 2018/10/22 | Accepted: 2019/08/4
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Baghfalaki T. Bayesian Sample Size Determination for Joint Modeling of Longitudinal Measurements and Survival Data. JSRI. 2019; 15 (2) :213-236
URL: http://jsri.srtc.ac.ir/article-1-309-en.html


Volume 15, Issue 2 (3-2019) Back to browse issues page
مجله‌ی پژوهش‌های آماری ایران (علمی - پژوهشی) Journal of Statistical Research of Iran JSRI
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